Work

Role of the renal androgen receptor in sex differences in ammonia metabolism

Year: 2021

Type: article

Abstract: Sexual dimorphisms in ammonia metabolism involve androgen receptor (AR)-dependent signaling pathways in male, but not female, kidneys that lead to altered proximal tubule (PT), phosphoenolpyruvate carboxykinase, and thick ascending limb Na + -K + -2Cl − cotransporter expression. Adaptive responses in Na + /H + exchanger 3 and electrogenic Na + -bicarbonate cotransporter 1-A expression limit the magnitude of the effect on ammonia excretion. Finally, the greater kidney size and PT volume density in male mice is the result of PT androgen signaling through AR.

Source: American Journal of Physiology-Renal Physiology

DOI: 10.1152/ajprenal.00260.2021

Authors: Autumn N. Harris, Rebeca A. Castro, Hyun-Wook Lee, Jill W. Verlander, I. David Weiner

Institutions: University of Florida Health, University of Florida, Veterans Health Administration

Language: English

Topic: Renal function and acid-base balance

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute of Diabetes and Digestive and Kidney Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development