Work

Beta-blockers reduce intestinal permeability and early mortality following traumatic brain injury in Drosophila

Year: 2021

Type: article

Abstract: flies the beta-blockers labetalol and metoprolol reduced intestinal permeability and mortality. Additionally, metoprolol reduced intestinal permeability when 18 DGRP fly lines were analyzed in aggregate, but neither beta-blocker affected mortality. These data indicate that the mechanism underlying disruption of the intestinal barrier by adrenergic signaling following TBI is conserved between humans and flies and that mortality following TBI in flies is not strictly dependent on disruption of the intestinal barrier. Thus, the fly TBI model is useful for shedding light on the mechanism and consequences of adrenergic signaling between the brain and intestine following TBI in humans.

Source: Europe PMC (PubMed Central)

DOI: 10.17912/micropub.biology.000461

Authors: Amanda R Scharenbrock, Rebeccah J Katzenberger, Megan C Fischer, Barry Ganetzky, David A Wassarman

Institution: University of Wisconsin–Madison

Language: English

Topic: Traumatic Brain Injury and Neurovascular Disturbances

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3204068643

FWCI: 0.599

Cites:

Cited by: 10

Related to: 10