Year: 2021
Type: review
Abstract: Animal and human laboratory paradigms offer invaluable approaches to study the complex etiologies and mechanisms of alcohol use disorder (AUD). We contend that human laboratory models provide a "bridge" between preclinical and clinical studies of AUD by allowing for well-controlled experimental manipulations in humans with AUD. As such, examining the consilience between experimental models in animals and humans in the laboratory provides unique opportunities to refine the translational utility of such models. The overall goal of the present review is to provide a systematic description and contrast of commonly used animal paradigms for the study of AUD, as well as their human laboratory analogs if applicable. While there is a wide breadth of animal species in AUD research, the paradigms discussed in this review rely predominately on rodent research. The overarching goal of this effort is to provide critical analysis of these animal models and to link them to human laboratory models of AUD. By systematically contrasting preclinical and controlled human laboratory models, we seek to identify opportunities to enhance their translational value through forward and reverse translation. We provide future directions to reconcile differences between animal and human work and to improve translational research for AUD.
Source: Translational Psychiatry
Institution: University of California, Los Angeles
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,380
Awards: Frontocortical Signaling Signatures in Flexible Reinforcement Learning, G2498272350, G252109679, Applying behavioral economics to screen medications for alcohol use disorder, G3724856018, UCLA Training Program in the Translational Neuroscience of Drug Abuse (TNDA), Clinical neuroscience of alcoholism: integrating neuroscience and clinical trials, Elucidating the Effects of Neuroimmune Modulation on Neural Substrates of Alcohol Cue and Stress Reactivity, G6125712913, G6427852226, G705043550, G7091984637, G8272250976, G8516285927, A randomized controlled clinical trial of the neuroimmune modulator ibudilast for the treatment of alcohol use disorder, G877280374, G8883621915, Cortico-Amygdalar Substrates of Adaptive Learning
OpenAlex ID: W3204412608