Year: 2021
Type: article
Abstract: The 6TM family of K channels comprises the voltage-gated KV subfamilies, the EAG subfamily (which includes hERG channels), the Ca2+-activated Slo subfamily (actually with 7TM, termed BK) and the Ca2+-activated SK subfamily. These channels possess a pore-forming α subunit that comprise tetramers of identical subunits (homomeric) or of different subunits (heteromeric). Heteromeric channels can only be formed within subfamilies (e.g. Kv1.1 with Kv1.2; Kv7.2 with Kv7.3). The pharmacology largely reflects the subunit composition of the functional channel.
Institutions: Tel Aviv University, University of California, Irvine, Columbia University, Universität Ulm, University of California, San Francisco, Centre National de la Recherche Scientifique, Stony Brook University, Washington University in St. Louis, Max Planck Institute of Experimental Medicine, University of Wisconsin–Madison, New York University, University of Utah, University of California, Davis, Chinese Academy of Medical Sciences & Peking Union Medical College
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W3204481869