Health Profile of Preterm Males With Duchenne Muscular Dystrophy
Year: 2021
Type: article
Study design: Observational Study
Abstract: In this retrospective cohort study, we characterize the health profile of preterm males with Duchenne muscular dystrophy. Major clinical milestones (ambulation cessation, assisted ventilation use, and onset of left ventricular dysfunction) and corticosteroids use in males with Duchenne muscular dystrophy identified through a population-based surveillance system were analyzed using Kaplan-Meier survival curves and Cox proportional hazards modeling. The adjusted risk of receiving any respiratory intervention among preterm males with Duchenne muscular dystrophy was 87% higher than among the corresponding full-term males with Duchenne muscular dystrophy. The adjusted risks for ambulation cessation and left ventricular dysfunction were modestly elevated among preterm compared to full-term males, but the 95% confidence intervals contained the null. No difference in the start of corticosteroid use between preterm and full-term Duchenne muscular dystrophy males was observed. Overall, the disease course seems to be similar between preterm and full-term males with Duchenne muscular dystrophy; however, pulmonary function seems to be affected earlier among preterm males with Duchenne muscular dystrophy.
Source: Journal of Child Neurology
Institutions: New York State Department of Health, Centers for Disease Control and Prevention, National Center on Birth Defects and Developmental Disabilities, Oak Ridge Institute for Science and Education, RTI International, East Tennessee State University, University of Mississippi Medical Center, University of Mississippi, University of Rochester
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Awards: G1146282228, G2257766211, SUREILLANCE AND EPIDEMIOLOGIC RESEARCH OF DUCHENNE AND BECKER MUSCULAR DYSTROPHY, THE MUSCULAR DYSTROPHY SURVEILLANCE, TRACKING AND RESEARCH NETWORK (MD STARNET) COMPONENT C-ENHANCED-DISSEMINATION, SURVEILLANCE AND EPIDEMIOLOGIC RESEARCH OF DUCHENNE AND BECKER MUSCULAR DYSTROPHY, G437812265, ARIZONA MUSCULAR DYSTROPHY SURVEILLANCE AND RESEARCH PROGRAM, G663124584, G7107615270, THE MUSCULAR DYSTROPHY SURVEILLANCE, TRACKING, AND RESEARCH NETWORK (MD STARNET): COMPONENT A - CORE-CURRENT SITE, SURVEILLANCE AND EPIDEMIOLOGIC RESEARCH OF DUCHENNE AND BECKER MUSCULAR DYSTROPHY, G7543494365, G7801193488, COMP A-SOUTH CAROLINA MD AND NEUROMUSCULAR DISORDERS SURVEILLANCE AND RES
OpenAlex ID: W3205110425