Year: 2020
Type: dissertation
Abstract: Due to the safety issues and poor engraftment of mesenchymal stem cell (MSC) implantation, MSC-derived exosomes have been spotlighted as an alternative therapy for wide variety of diseases including myocardial infarction (MI) and spinal cord injury (SCI).Despite of the advantages of exosomes over MSC therapies, there are several limitations for clinical application due to the very small productivity and poor targeting ability to diseased organs after administration.To overcome these obstacles, exosome-mimetic extracellular nanovesicles (NVs) have been iii function.These results present their possibility of clinical application for SCI.Together, we showed that NVs derived from IONP-MSCs or MF-MSCs contain greater therapeutic molecules or targeting molecules that can facilitate enhanced accumulation in infarcted myocardium or injured spinal cord.Our novel approach to augment therapeutic efficacy of NVs derived from modified MSCs can be a good replacement of conventional MSC or MSC-derived exosome therapies.Our technology can be applied the clinical applications in the future as therapies for acute ischemic/inflammatory diseases.
Author: 이주로
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3205253778