Application of Photochemical/Electrochemical Synthesis in C—H Functionalization of Quinoxalin-2(1H)-one
Year: 2021
Type: article
Abstract: Quinoxalin-2(1H)-ones are a kind of important nitrogen-containing heterocyclic compounds, which have strong biological activity and chemical properties, and play an important role in synthesis chemistry, functional materials, drugs and so on.In recent years, the construction of 3-functionalized quinoxalin-2(1H)-one by C-H functionalization has attracted the attention of many scholars and made important progress.Among them, green chemistry oriented photocatalysis and electrochemical synthesis are becoming powerful tools for C-H functionalization of quinoxaline-2(1H)-one.In view of the great influence of photochemistry in synthetic chemistry, the research status of C-H functionalization of quinoxaline-2(1H)-one in visible light catalysis and electrochemical synthesis is summarized, hoping to promote the further development of green synthesis strategy in the functionalization of nitrogen-containing heterocycles.Keywords quinoxalin-2(1H)-one; visible-light; electrochemistry; C-H functionalization 喹喔啉-2(1H)-酮作为一种重要的含氮杂环单元, 具 有很强的生物活性与优异的化学特性, 并背被泛应用于 合成化学、材料、天然产物和药物工业领域 [1] .其中, 3-取代的喹喔啉酮-2(1H)-酮表现出独特特性和生物活性, 常被开发成潜在的强效药物, 如抗肿瘤药、 抗糖尿病药、 抗炎药、减肥药及心血管药等 [2] (图 1).近年来, 喹喔啉-2(1H)-酮的直接官能化引起了很多学者的兴趣, 极大地 满足了高通量药物筛选的要求.其中, C-H 官能化反应 成为了合成喹喔啉-2(1H)-酮衍生物的有效策略, 通过 C-H 官能化反应可以有效地构建 C-X 键 [3] (如 C-C 键、C-O 键、C-N 键、C-S 键、C-P 键等), 从而实 现喹喔啉-2(1H)-酮的烷基化、芳基化、酰基化、三氟甲 基化、烷氧基化、亚磺酰化、硅烷化、磷酸化和醚化等 (Scheme 1) [4] .
Authors: Xiang Liu, Wen Li, Canzhan Zhuang, Hua Cao
Institution: Guangdong Pharmaceutical University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W3205271229