Targeted Anti‐Tumor Immunotherapy Using Tumor Infiltrating Cells
Year: 2021
Type: article
Abstract: In the tumor microenvironment, T cells, B cells, and many other cells play important and distinct roles in anti‐tumor immunotherapy. Although the immune checkpoint blockade and adoptive cell transfer can elicit durable clinical responses, only a few patients benefit from these therapies. Increased understanding of tumor‐infiltrating immune cells can provide novel therapies and drugs that induce a highly specific anti‐tumor immune response to certain groups of patients. Herein, the recent research progress on tumor‐infiltrating B cells and T cells, including CD8 + T cells, CD4 + T cells, and exhausted T cells and their role in anti‐tumor immunity, is summarized. Moreover, several anti‐tumor therapy approaches are discussed based on different immune cells and their prospects for future applications in cancer treatment.
Source: Advanced Science
Authors: Yifan Xie, Feng Xie, Lei Zhang, Xiaoxue Zhou, Jun Huang, Fangwei Wang, Jin Jin, Long Zhang, Linghui Zeng, Fangfang Zhou
Institutions: Zhejiang University, Soochow University, Ruian People's Hospital
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $5,000
Funders: Ministry of Science and Technology, National Natural Science Foundation of China, Natural Science Foundation of Jiangsu Province, Priority Academic Program Development of Jiangsu Higher Education Institutions, Jiangsu Provincial Key Research and Development Program, Medical and Health Research Project of Zhejiang Province, Natural Science Foundation of Zhejiang Province
OpenAlex ID: W3205309803