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Commentary on Population matched (pm) germline allelic variants of immunoglobulin (IG) loci: relevance in infectious diseases and vaccination studies in human populations

Year: 2021
Type: editorial
Abstract: In their recent publication, Khatri et al. [ 1 ] describe an immunoglobulin germline gene database inferred from short-read genomic sequence data derived from five superpopulations. The development of methods for the compilation of more complete and accurate germline gene databases would be an important achievement, but we do not believe that this has been achieved. Existing databases are clearly incomplete. Germline sequences differ substantially between subjects, and alleles found in some populations may be absent in others. Existing databases are likely biased towards alleles found in European populations and may lack many sequences found in understudied populations [ 2 ]. Improved, properly designed and curated germline gene databases are therefore needed for analysis of antibody repertoires.
DOI: 10.1038/s41435-021-00152-6
Authors: Andrew M. Collins, Ayelet Peres, Martin M. Corcoran, Corey T. Watson, Gur Yaari, William D. Lees, Mats Ohlin
Institutions: UNSW Sydney, Bar-Ilan University, Karolinska Institutet, University of Louisville, University of London, Institute of Structural and Molecular Biology, Birkbeck, University of London, Lund University
Language: English
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $3,165
OpenAlex ID: W3205314208
Cites: 17
Cited by: 22
Related to: 10