Work

Evolutionarily conserved clusters of colon with lung cancer susceptibility loci, linked with most DUSP phosphatase genes, may help to dissect mechanisms of cancer susceptibility

Year: 2021

Type: preprint

Abstract: We show evolutionarily conserved pairwise genetic linkage and clustering of majority of colon and lung cancer susceptibility QTLs in mice, rats and humans. The patterns of susceptibility or resistance to these two cancers in recombinant congenic mouse strains were concordant and the responsible susceptibility loci closely linked, in spite of completely different carcinogens and protocols used for induction of the two tumors. Most DUSP (Dual specificity phosphatase) genes are linked to these clusters. These data suggest that an important part of colon and lung cancer susceptibility is controlled by related and evolutionarily conserved processes.

Source: bioRxiv (Cold Spring Harbor Laboratory)

DOI: 10.1101/2021.10.13.461047

Authors: Lei Quan, Miranda L. Lynch, Peter Demant

Institutions: Tianjin University of Sport, Hauptman-Woodward Medical Research Institute, Roswell Park Comprehensive Cancer Center

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Roswell Park Cancer Institute, Thousand Young Talents Program of China, National Cancer Institute