Work

Regulation of Partial and Reversible Endothelial-to-Mesenchymal Transition in Angiogenesis

Year: 2021

Type: article

Abstract: During development and in several diseases, endothelial cells (EC) can undergo complete endothelial-to-mesenchymal transition (EndoMT or EndMT) to generate endothelial-derived mesenchymal cells. Emerging evidence suggests that ECs can also undergo a partial EndoMT to generate cells with intermediate endothelial- and mesenchymal-character. This partial EndoMT event is transient, reversible, and supports both developmental and pathological angiogenesis. Here, we discuss possible regulatory mechanisms that may control the EndoMT program to dictate whether cells undergo complete or partial mesenchymal transition, and we further consider how these pathways might be targeted therapeutically in cancer.

Source: Frontiers in Cell and Developmental Biology

DOI: 10.3389/fcell.2021.702021

Authors: Jennifer S. Fang, Nan W. Hultgren, Christopher C. W. Hughes

Institutions: University of California, Irvine, University of California, Los Angeles

Language: English

Topic: Angiogenesis and VEGF in Cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,950