Year: 2021
Type: review
Abstract: Differentiation of human-induced pluripotent stem cells (hiPSCs) toward kidney organoids is known to suffer from batch-to-batch differences, off-target populations, and skewered cellular compositions. Application of synthetic hydrogels as a tool for hiPSC-differentiation may provide additional control over this variable process. This review discusses important material properties that affect kidney organoid generation. We summarize cellular adhesive cues for synthetic materials, that allow transduction of the mechanical forces to the cell, and how these signals directly affect Hippo-Canonical Wnt signaling and morphogenic events. In addition, chemical strategies are discussed that allow spatiotemporal presentation of biochemical agents to the cell in a material-dependent approach.
Institution: Eindhoven University of Technology
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $3,750
Awards: Materials-driven regeneration: Regenerating tissue and organ function with intelligent, life-like materials, G1440364473, G420050720, G5348650765, G6330235322, Engineering function into elastomeric materials using supramolecular interactions – en route to meet nature’s complexity in plastics
OpenAlex ID: W3205606866