Influence of red blood cell indices on HbA1c performance in detecting dysglycaemia in a Singapore preconception cohort study
Year: 2021
Type: article
Study design: Observational Study
Abstract: Abnormalities of red blood cell (RBC) indices may affect glycated haemoglobin (HbA1c) levels. We assessed the influence of haemoglobin (Hb) and mean corpuscular volume (MCV) on the performance of HbA1c in detecting dysglycaemia among reproductive aged women planning to conceive. Women aged 18-45 years (n = 985) were classified as normal (12 ≤ Hb ≤ 16 g/dL and 80 ≤ MCV ≤ 100 fL) and abnormal (Hb < 12 g/dL and/or MCV < 80 fL). The Area Under the Receiver Operating Characteristic (AUROC) curve was used to determine the performance of HbA1c in detecting dysglycaemic status (prediabetes and diabetes). There were 771 (78.3%) women with normal RBC indices. The AUROCs for the normal and abnormal groups were 0.75 (95% confidence interval 0.69, 0.81) and 0.80 (0.70, 0.90), respectively, and were not statistically different from one another [difference 0.04 (- 0.16, 0.08)]. Further stratification by ethnicity showed no difference between the two groups among Chinese and Indian women. However, Malay women with normal RBC indices displayed lower AUROC compared to those with abnormal RBC indices (0.71 (0.55, 0.87) vs. 0.98 (0.93, 1.00), p = 0.002). The results suggest that the performance of HbA1c in detecting dysglycaemia was not influenced by abnormal RBC indices based on low Hb and/or low MCV. However, there may be ethnic variations among them.
Source: Scientific Reports
Institutions: Agency for Science, Technology and Research, Singapore Institute for Clinical Sciences, KK Women's and Children's Hospital, Duke-NUS Medical School, Tampere University, University of Tampere, National Health Service, University Hospital Southampton NHS Foundation Trust, MRC Lifecourse Epidemiology Unit, University of Southampton, National University of Singapore, National University Hospital, National University Health System, Nanyang Technological University, Tan Tock Seng Hospital, SingHealth, SingHealth Duke-NUS Academic Medical Centre
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,990
Funders: National Institute for Health and Care Research, British Heart Foundation, European Commission, National Research Foundation, Singapore Institute for Clinical Sciences, National Research Foundation Singapore, National University Health System, National Institute for Health Research Southampton Biomedical Research Centre, Medical Research Council, National Medical Research Council, Erasmus+, Precursory Research for Embryonic Science and Technology
Awards: G1321528303, Programme 1: Musculoskeletal health in later life, G1659327504, G1727471521, G1917706474, G1956390128, G195975639, G2125390887, G2154835441, G2400945375, G2693923786, G2780654756, G2838213439, G3210728687, G3424013768, NIHR Senior Investigator Award, G3521509650, G3778457340, G3873828540, G389277099, G427574963, NIHR Senior Investigator Award, Capacity Building to Improve Early Nutrition and Health in South Africa, Programme 3: Early development and risk of adult musculoskeletal disease, G4964355645, G5023485246, G5224105001, G524590474, G5318721926, G5755632036, G606602278, G6206044308, G6408020244, G645171559, G6823649948, G6907919727, G71336211, G7348633402, G7388601084, G740803340, MRC Lifecourse Epidemiology Centre - Core Support, G7485733262, G7633864364, G7643966348, G7671148335, G7852524164, G7865205193, G8346907872, G8385395667, Nutrition, Development and Lifelong Health: Studies in European Populations, G8606453147
OpenAlex ID: W3205932230