New Approaches to Glioblastoma
Year: 2021
Type: review
Abstract: Faced with unique immunobiology and marked heterogeneity, treatment strategies for glioblastoma require therapeutic approaches that diverge from conventional oncological strategies. The selection and prioritization of targeted and immunotherapeutic strategies will need to carefully consider these features and companion biomarkers developed alongside treatment strategies to identify the appropriate patient populations. Novel clinical trial strategies that interrogate the tumor microenvironment for drug penetration and target engagement will inform go/no-go later-stage clinical studies. Innovative trial designs and analyses are needed to move effective agents toward regulatory approvals more rapidly.
Source: Annual Review of Medicine
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1174881085, G154325233, G3037530914, G3726279683, Genetic Approaches to Optimize CAR T cells for Glioblastoma Therapy, Stinging the Glioma Immune Landscape, Modulation of Microglia and T Cell Interactions in Malignant Glioma, Understanding the Behavior of Novel IL13Ralpha2-directed T cell Engager for GBM, Cancer Center Support Grant (CCSG), Development of B-cell-based vaccine for Glioblastoma
OpenAlex ID: W3205968074