Preparation and in vivo/in vitro characterization of Ticagrelor PLGA sustained-release microspheres for injection
Year: 2021
Type: article
Abstract: The objective of this paper was to develop a PLGA carrier Ticagrelor sustained-release microspheres preparation, which was expected to continue to release Ticagrelor for 14 days with a high encapsulation rate. Ticagrelor microspheres were prepared successfully with average diameter of 7.31 µm, drug loading of 12.49 ± 0.32% and EE up to 79.09 ± 1.69%. In the release medium of PH7.4 PBS, the microspheres showed good drug release behavior in vitro. In vivo release results also showed that the sustained-release microspheres could effectively control drug release in vivo and maintain a relatively stable blood drug concentration for about 2 weeks. The results indicate that Ticagrelor sustained-release microspheres can be used for long-term treatment of acute coronary syndrome.
Source: Designed Monomers & Polymers
Authors: Linkun Hao, Yunying Jiang, Ru Zhang, Ningning Zhang, Yang Yang, Ying Gao, Yimin Song
Institution: Qingdao University of Science and Technology
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,533
OpenAlex ID: W3205990148