Work

REDD1 deletion attenuates cancer cachexia in mice

Year: 2021

Type: article

Abstract: Cancer cachexia is a debilitating and lethal consequence of many advanced cancers. REDD1, a negative regulator of mTORC1 activity, is an emerging target in cachexia. Our data show that skeletal muscle REDD1 expression is increased in LLC-induced cancer cachexia. Mice lacking REDD1 have attenuated skeletal muscle atrophy that is likely due to maintaining both protein synthesis and inhibiting protein degradation.

Source: Journal of Applied Physiology

DOI: 10.1152/japplphysiol.00536.2021

Authors: Brian A. Hain, Haifang Xu, Ashley M. VanCleave, Bradley S. Gordon, Scot R. Kimball, David L. Waning

Institutions: Pennsylvania State University, Penn State Cancer Institute, Penn State Milton S. Hershey Medical Center, Florida State University

Language: English

Topic: Muscle Physiology and Disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute of Diabetes and Digestive and Kidney Diseases, Penn State Hershey Cancer Institute