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The interaction of lipids and inflammatory markers predict negative symptom severity in patients with schizophrenia

Year: 2021
Type: article
Study design: Observational Study
Abstract: Finding biological predictors and novel mechanisms underlying negative symptoms of schizophrenia is of significant importance given the lack of effective treatments. Increasing data support a role for metabolic dysfunction and inflammation in reward processing deficits in psychiatric illness. Herein, we found an interaction between lipids and inflammation as a predictor of worse negative symptom severity in individuals with schizophrenia. Future studies may seek to further elucidate this relationship and thereby reveal novel treatment targets for negative symptoms.
DOI: 10.1038/s41537-021-00179-8
Language: English
Field: Medicine
Open Access status: gold
Estimated APC paid: $3,590
Funders: U.S. Department of Health and Human Services, U.S. Department of Veterans Affairs, Office of Research and Development, Emory University, National Institutes of Health, School of Medicine, Emory University, National Institute of Mental Health
Awards: G1065585915, G2741871152, G3118087601, G3244132693, G4291216142, G569003154, G6109701232, The role of kynurenine pathway activation in Toxoplasma-linked schizophrenia, Impact of Inflammation on Reward Circuits, Motivational Deficits and Negative Symptoms in Schizophrenia, Molecular pathways of the kynurenine system in the neuroimmunology and psychophysiology of schizophrenia.
OpenAlex ID: W3206206046
FWCI: 1.74
Cites: 17
Cited by: 18
Related to: 10