Work

Reconstruction of evolving gene variants and fitness from short sequencing reads

Year: 2021

Type: article

Source: Nature Chemical Biology

DOI: 10.1038/s41589-021-00876-6

Authors: Max W. Shen, Kevin T. Zhao, David R. Liu

Institutions: Broad Institute, Howard Hughes Medical Institute, Harvard University

Language: English

Topic: Evolution and Genetic Dynamics

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Howard Hughes Medical Institute, U.S. Department of Health and Human Services, National Human Genome Research Institute, National Institute of General Medical Sciences, National Institute of Biomedical Imaging and Bioengineering

Awards: Graduate Training in Computational and Systems Biology, G2304256781, G4630203202, G6316350344, Continuous Evolution of Proteins with Novel Therapeutic Potential, ePACE: automation platforms for adaptable and scalable continuous evolution of biomolecules with therapeutic potential, Integrating Chemistry and Evolution to Illuminate Biology and Enable Novel Therapeutics, Center for Genomic Editing and Recording: Development and Application of Next-Generation Genome and Epigenome Editing Methods to Advance the Study and Treatment of Human Disease

OpenAlex ID: W3206418085

FWCI: 1.834

Cites: 56

Cited by: 18

Related to: 10