Work

A Protocol for the Ortho -Deuteration of Acidic Aromatic Compounds in D 2 O Catalyzed by Cationic Rh III

Year: 2019

Type: article

Abstract: Methods to catalytically introduce deuterium in synthetically useful yields ortho to a carboxylic acid directing group on arenes typically requires D2 or CD3CO2D, which makes using these approaches cost prohibitive for large scale synthesis (equipment and reagent costs respectively). Herein we present a simplified approach using catalytic RhIII and D2O as deuterium source, and show its application to H/D exchange on various acidic substrates.

Source: Organic Letters

DOI: 10.1021/acs.orglett.9b02618

Authors: Alyssa L. Garreau, Hanyang Zhou, Michael C. Young

Institution: University of Toledo

Language: English

Topic: Chemical Reactions and Isotopes

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: green

Funders: Herman Frasch Foundation for Chemical Research, University of Toledo

Award: G8021022995