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First- and Third-Trimester Urinary Phthalate Metabolites in the Development of Hypertensive Diseases of Pregnancy

Year: 2021
Type: article
Study design: Observational Study
Abstract: The purpose of this study was to determine whether maternal urinary phthalate metabolite concentrations are associated with the development of higher blood pressure or pregnancy-induced hypertension (PIH). Participants were women without chronic hypertension who enrolled in The Infant Development and the Environment Study, a prospective pregnancy cohort conducted at four U.S. academic medical centers from 2010-2012. Prenatal records were reviewed to obtain blood pressure measurements and diagnoses of PIH (gestational hypertension, preeclampsia, eclampsia, and HELLP syndrome, defined as hemolysis, elevated liver enzymes, and low platelet count). Complete-case analyses used multivariable linear and logistic regression for analysis of blood pressure measurements and PIH diagnoses, respectively. In the final dataset (N = 668), higher concentrations of first-trimester monoethyl phthalate (MEP) and mono-3-carboxypropyl phthalate (MCPP) and third-trimester mono-isobutyl phthalate (MiBP) were significantly associated with a medical chart diagnosis of PIH. First-trimester mono-n-butyl phthalate (MBP) and MEP along with the sum of di-(2-ethylhexyl) phthalate metabolites (∑DEHP) were each associated with increased systolic blood pressure across pregnancy. In conclusion, several phthalate metabolite concentrations were significantly associated with PIH and greater increases in systolic blood pressure across pregnancy.
DOI: 10.3390/ijerph182010627
Authors: Sabrina M. Bedell, Grace R. Lyden, Sheela Sathyanarayana, Emily S. Barrett, Kelly K. Ferguson, Ashley Santilli, Nicole R. Bush, Shanna H. Swan, Thomas F. McElrath, Ruby H.N. Nguyen
Institutions: University of Minnesota, Cleveland Clinic, University of Washington, Seattle Children's Research Institute, Rutgers, The State University of New Jersey, Environmental and Occupational Health Sciences Institute, National Institute of Environmental Health Sciences, Mayo Clinic, University of California, San Francisco, Icahn School of Medicine at Mount Sinai, Brigham and Women's Hospital, Harvard University
Language: English
Open Access status: gold
Estimated APC paid: $2,484
Awards: G3979804608, The Infant Development and the Environmental Study (TIDES), G727370032, Phthalate and stressful life event exposures and pregnancy outcomes: The role of oxidative stress, G9000261527, Rutgers Center for Environmental Exposure and Disease (CEED), G979940031
OpenAlex ID: W3206490573
FWCI: 2.137
Cites: 36
Cited by: 34
Related to: 10