Year: 2021
Type: review
Abstract: Infectious diseases affect individual health and have widespread societal impacts. New ex vivo models are critical to understand pathogenesis, host response, and features necessary to develop preventive and therapeutic treatments. Pluripotent and tissue stem cell-derived organoids provide new tools for the study of human infections. Organoid models recapitulate many characteristics of in vivo disease and are providing new insights into human respiratory, gastrointestinal, and neuronal host-microbe interactions. Increasing culture complexity by adding the stroma, interorgan communication, and the microbiome will improve the use of organoids as models for infection. Organoid cultures provide a platform with the capability to improve human health related to infectious diseases.
Source: Annual Review of Medicine
Authors: Sarah E. Blutt, Mary K. Estes
Institution: Baylor College of Medicine
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
Awards: Limited Competition for the Continuation of the Intestinal Stem Cell Consortium Coordinating Center, Mechanisms of Norovirus Pathogenesis and Replication to Develop Therapeutics, Integrated Genomics of Mucosal Infections, Intestinal Niche in Homeostasis and Epithelial Regeneration, Intestinal Stem Cell Consortium Coordinating Center, Texas Medical Center Digestive Diseases Center, Human Biomimetics for Mucosal Infections
OpenAlex ID: W3206497217