Year: 2021
Type: review
Abstract: Exosomes (EXs), a type of extracellular vesicles, are secreted from virtually all types of cells. EXs serve as cell-to-cell communicators by conveying proteins and nucleic acids with regulatory functions. Increasing evidence shows that EXs are implicated in the pathogenesis of central nervous system (CNS) diseases. Moreover, EXs have recently been highlighted as a new promising therapeutic strategy for in vivo delivery of nucleotides and drugs. Studies have revealed that infusion of EXs elicits beneficial effects on the CNS injury animal models. As compared to cell-based therapy, EXs-based therapy for CNS diseases has unique advantages, opening a new path for neurological medicine. In this review, we summarized the current state of knowledge of EXs, the roles and applications of EXs as a viable pathological biomarker, and EX-based therapy for CNS diseases.
Source: CNS Neuroscience & Therapeutics
DOI: 10.1111/cns.13743
Authors: Jared Mattingly, Yuchen Li, Ji C. Bihl, Jinju Wang
Institutions: Marshall University, Wright State University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,530
Awards: G1245801999, The regulatory effect of exercise on circulating EPC-EXs and its implication in ischemic stroke, Exosomes from miR-primed endothelial progenitor cells for treating ischemic stroke, G8914166701, West Virginia Clinical and Translational Science Institute: A Statewide Organization Building Research Excellence and Engaging Communities to Improve Health
OpenAlex ID: W3206512453