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Experimental and clinical evidence suggests that GRPEL2 plays an oncogenic role in HCC development.

Year: 2021

Type: article

Abstract: . Moreover, GRPEL2 deficiency also accelerated reactive oxygen species (ROS) production and increased mitochondrial membrane potential (MMP), leading to cell apoptosis. In addition, we found that the cell cycle and NF-κB signaling pathways were responsible for GRPEL2-induced HCC progression, based on the results of Gene Set Enrichment Analysis (GSEA) and subsequent experimental validation. Our study, for the first time, identified the role of GRPEL2 in HCC development and provided a compelling biomarker for targted therapy in HCC treatment.

Source: PubMed

Authors: Ming-Chun Lai, Qian-Qian Zhu, Jun Xu, Wen-Jin Zhang

Institutions: First Affiliated Hospital Zhejiang University, Zhejiang University

Language: English

Topic: Hepatocellular Carcinoma Treatment and Prognosis

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3206645413

FWCI: 0.705

Cites: 40

Cited by: 11

Related to: 10