Plasma nontransferrin bound iron– nontransferrin bound iron revisited: Implications for systemic iron overload and in iv iron supplementation
Year: 2021
Type: article
Abstract: Nontransferrin bound iron (NTBI) has been classically used to denote a potentially toxic component of plasma detected in systemic iron overload and implicated in end-organ iron accumulation and biological damage.A chelatable labile component of plasma NTBI has also served as target for novel therapeutics.However, as the term NTBI per se does not exclude nontoxic forms of iron that can be detected in plasma, its liberal use without additional pharmacological attributes might be misleading, especially in the clinical context, as for infusible iron supplements.In keeping with the historical and commonly used NTBI term, we propose here to use "labile/nonlabile" plasma NTBI to
Source: American Journal of Hematology
DOI: 10.1002/ajh.26374
Authors: Ioav Z. Cabantchik, Chaim Hershko
Institution: Hebrew University of Jerusalem
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W3206667567