Work

Author Correction: Development and Evaluation of 18F-IRS for Molecular Imaging Mutant EGF Receptors in NSCLC

Year: 2021

Type: erratum

Abstract: In Figure 5A, the blots for EGFR (E746-A750del) and GAPDH band are incorrect, which affected the quantification in Figure 5B. A corrected version of Figure 5 and its accompanying legend appear below. Figure 5 Western blot and immunofluorescence of tumors derived from HCC827, H520, H1975 and H358 cell lines. ( A ) Representative Western blots of four human NSCLC tissue lysates comparing the extent of EGFR and EGFR-specific E749-A750del mutation expression. GAPDH served as a reference for equal loading. HCC827 tissue has high EGFR and EGFR-specific E749-A750del mutation EGFR ( B ) Western blot analysis of proteins in total EGFR and EGFR-specific E749-A750del mutation (n = 3). Data are presented as mean ± SD. * P < 0.05 vs. HCC827 group in total EGFR. ** P < 0.01 vs. HCC827 group in total EGFR. ## P < 0.01 vs. HCC827 group in EGFR-specific E749-A750del mutation. ( C ) The immunofluorescence in tumors confirms western blot results. (Red color is from secondary antibody Alexa Fluor®549, and blue color from DAPI for nuclear visualization). All scale bars, 100 μm. Full size image

Source: Scientific Reports

DOI: 10.1038/s41598-021-99707-w