NormVAE: Normative Modeling on Neuroimaging Data using Variational Autoencoders.
Year: 2021
Type: preprint
Abstract: Normative modeling is an emerging method for understanding the heterogeneous biology underlying neuropsychiatric and neurodegenerative disorders at the level of the individual participant. Deep autoencoders have been implemented as normative models, where patient-level deviations are modelled as the squared difference between the actual and reconstructed input without any uncertainty estimates in the deviations. In this study, we assessed NormVAE, a novel normative modeling based variational autoencoder (VAE) which calculates subject-level normative abnormality maps (NAM) for quantifying uncertainty in the deviations. Our experiments on brain neuroimaging data of Alzheimer's Disease (AD) patients demonstrated that the NormVAE-generated patient-level abnormality maps exhibit increased sensitivity to disease staging compared to a baseline VAE, which generates deterministic subject-level deviations without any uncertainty estimates.
Source: arXiv (Cornell University)
Authors: Sayantan Kumar, Aristeidis Sotiras
Institution: Washington University in St. Louis
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3206816245