Work

CSE1L silencing impairs tumor progression via MET/STAT3/PD-L1 signaling in lung cancer.

Year: 2021

Type: article

Abstract: level was correlated with worse patient outcome. Knockdown of CSE1L using siRNAs impaired cell proliferation, invasion, migration and induced cell apoptosis. Mechanistically, MET, STAT3 and PD-L1 proteins were decreased upon CSE1L silencing. These results suggest that CSE1L may affect tumor progression through MET/STAT3/PD-L1 signaling. CSE1L may have potential as a biomarker and therapeutic target for lung cancer.

Source: PubMed Central

Authors: Weijun Liu, Zhiqing Zhou, Yu Li, Jiali Xu, Yang Shen, Suisui Luo, Yujie Zhou, Xing Wu, Huijie Zhao, David G Beer, Yanli He, Guoan Chen

Institutions: Kunming University of Science and Technology, First People's Hospital of Yunnan Province, Southern University of Science and Technology, University of Michigan, Michigan Medicine, Guangzhou University of Chinese Medicine

Language: English

Topic: Lung Cancer Research Studies

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3207000161

FWCI: 0.733

Cites: 59

Cited by: 10

Related to: 10