Year: 2021
Type: article
Abstract: While canonical and non-canonical functions of pyruvate kinase M2 (PKM2) are recognized to mediate often-opposing roles in cancer, its contribution to cellular and systemic fatty acid homeostasis remains poorly understood. A new study by Liu et al (2021) uncovers ER transmembrane protein TMEM33 as a novel target of PKM2, which is essential for regulation of cancer cell cholesterol metabolism. These findings highlight the diversity of tissue-specific functions of PKM2 and potential implications for cancer treatment.
Source: The EMBO Journal
Authors: Ali Khateb, Ze’ev A Ronai
Institution: Sanford Burnham Prebys Medical Discovery Institute
Language: Indonesian
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $5,200
Funder: National Cancer Institute
OpenAlex ID: W3207103839