Work

Progressive alterations in amino acid and lipid metabolism correlate with peripheral neuropathy in Polg D257A mice

Year: 2021

Type: article

Abstract: Alanine accumulation in Polg D257A mice links mitochondrial defects to 1-deoxysphingolipids and peripheral neuropathy.

Source: Science Advances

DOI: 10.1126/sciadv.abj4077

Authors: Esther W. Lim, Michal K. Handzlik, Elijah Trefts, Jivani M. Gengatharan, Carlos M. Pondevida, Reuben J. Shaw, Christian M. Metallo

Institutions: Salk Institute for Biological Studies, University of California San Diego

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,500

Funders: National Institutes of Health, University of California, San Diego, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: Non-essential amino acids and sphingolipid diversity in cancer progression, G2455522062, G2607907475, Decoding regulation of glucose homeostasis and metabolic responses to mitochondrial stress by AMPK, G586579722, G680976502, G9000036316, G9000050201, G9000093918, Cancer Center Support Grant (CCSG)

OpenAlex ID: W3207830422

FWCI: 0.87

Cites: 89

Cited by: 20

Related to: 10