Emerging Roles of Energy Metabolism in Ferroptosis Regulation of Tumor Cells

Year: 2021

Type: review

Abstract: Ferroptosis is a new form of regulated cell death, which is characterized by the iron-dependent accumulation of lethal lipid peroxides and involved in many critical diseases. Recent reports revealed that cellular energy metabolism activities such as glycolysis, pentose phosphate pathway (PPP), and tricarboxylic acid cycle are involved in the regulation of key ferroptosis markers such as reduced nicotinamide adenine dinucleotide phosphate (NADPH), glutathione (GSH), and reactive oxygen species (ROS), therefore imposing potential regulatory roles in ferroptosis. Remarkably, tumor cells can activate adaptive metabolic responses to inhibit ferroptosis for self-preservation such as the upregulation of glycolysis and PPP. Due to the rapid proliferation of tumor cells and the intensified metabolic rate, tumor energy metabolism has become a target for disrupting the redox homeostasis and induce ferroptosis. Based on these emerging insights, regulatory impact of those-tumor specific metabolic aberrations is systematically characterized, such as rewired glucose metabolism and metabolic compensation through glutamine utilization on ferroptosis and analyzed the underlying molecular mechanisms. Additionally, those ferroptosis-based therapeutic strategies are also discussed by exploiting those metabolic vulnerabilities, which may open up new avenues for tumor treatment in a clinical context.

Source: Advanced Science

DOI: 10.1002/advs.202100997

Authors: Xuemei Yao, Wei Li, De Fang, Chuyu Xiao, Xiao Wu, Menghuan Li, Zhong Luo

Institutions: Chongqing University, Chongqing Cancer Hospital

Language: English

Topic: Ferroptosis and cancer prognosis

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,000

Funders: National Natural Science Foundation of China, Chongqing Science and Technology Commission, Natural Science Foundation of Chongqing, Chongqing Municipal Education Commission, Key Technologies Research and Development Program, National Key Research and Development Program of China, Fundamental Research Funds for the Central Universities

OpenAlex ID: W3207848283