Progress Identifying and Analyzing the Human Proteome: 2021 Metrics from the HUPO Human Proteome Project
Year: 2021
Type: article
Abstract: The 2021 Metrics of the HUPO Human Proteome Project (HPP) show that protein expression has now been credibly detected (neXtProt PE1 level) for 18 357 (92.8%) of the 19 778 predicted proteins coded in the human genome, a gain of 483 since 2020 from reports throughout the world reanalyzed by the HPP. Conversely, the number of neXtProt PE2, PE3, and PE4 missing proteins has been reduced by 478 to 1421. This represents remarkable progress on the proteome parts list. The utilization of proteomics in a broad array of biological and clinical studies likewise continues to expand with many important findings and effective integration with other omics platforms. We present highlights from the Immunopeptidomics, Glycoproteomics, Infectious Disease, Cardiovascular, Musculo-Skeletal, Liver, and Cancers B/D-HPP teams and from the Knowledgebase, Mass Spectrometry, Antibody Profiling, and Pathology resource pillars, as well as ethical considerations important to the clinical utilization of proteomics and protein biomarkers.
Source: Journal of Proteome Research
Institutions: University of Michigan, Institute for Systems Biology, SIB Swiss Institute of Bioinformatics, University of British Columbia, Yonsei University, Yonsei Proteome Research Center, Princeton University, Centro Nacional de Biotecnología, Uppsala University, The University of Texas at San Antonio Health Science Center, Memorial Sloan Kettering Cancer Center, BGI Group (China), University of California San Diego, National Cancer Institute, National Taiwan University, Academia Sinica, University of Zurich, ETH Zurich
Language: English
Subfield: Spectroscopy
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
Funders: National Science Foundation, Farmer Family Foundation, Knut och Alice Wallenbergs Stiftelse, Swiss Institute of Bioinformatics, National Institutes of Health, Canadian Institutes of Health Research, National Health and Medical Research Council, National Institute on Aging, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Environmental Health Sciences
Awards: G1371608312, G256124583, Integrative Omics to enhance therapeutics development for healthy aging, G4498387036, G5069345040, G5382949092, G5947130320, Mechanisms mediating immune response upon sensing of nuclear viral DNA, G6272797926, G6307227167, G6506177523, Membrane Proteins Interact in Colorectal Cancer, G74609444, G7886340453, G827738197, G9000017640, G9000036887, G9000045943, G9000062248, G9000086042, G9000132795, G9000230861, G9000325104, Cancer Center Support Grant
OpenAlex ID: W3207926977