Obesity during childhood is associated with higher cancer mortality rate during adulthood: the i3C Consortium
Year: 2021
Type: article
Abstract: BACKGROUND: In high-income countries, cancer is the leading cause of death among middle-aged adults. Prospective data on the effects of childhood risk exposures on subsequent cancer mortality are scarce. METHODS: We examined whether childhood body mass index (BMI), blood pressure, glucose and lipid levels were associated with adult cancer mortality, using data from 21,012 children enrolled aged 3-19 years in seven prospective cohort studies from the U.S., Australia, and Finland that have followed participants from childhood into adulthood. Cancer mortality (cancer as a primary or secondary cause of death) was captured using registries. RESULTS: 354 cancer deaths occurred over the follow-up. In age-, sex, and cohort-adjusted analyses, childhood BMI (Hazard ratio [HR], 1.13; 95% confidence interval [CI] 1.03-1.24 per 1-SD increase) and childhood glucose (HR 1.22; 95%CI 1.01-1.47 per 1-SD increase), were associated with subsequent cancer mortality. In a multivariable analysis adjusted for age, sex, cohort, and childhood measures of fasting glucose, total cholesterol, triglycerides, and systolic blood pressure, childhood BMI remained as an independent predictor of subsequent cancer mortality (HR, 1.24; 95%CI, 1.03-1.49). The association of childhood BMI and subsequent cancer mortality persisted after adjustment for adulthood BMI (HR for childhood BMI, 1.35; 95%CI 1.12-1.63). CONCLUSIONS: Higher childhood BMI was independently associated with increased overall cancer mortality.
Source: International Journal of Obesity
Authors: Joel Nuotio, Tomi T. Laitinen, Alan R. Sinaiko, Jessica G. Woo, Elaine M. Urbina, David R. Jacobs, Julia Steinberger, Ronald J. Prineas, Matthew A. Sabin, David P. Burgner, Heikki Minn, Trudy L. Burns, Lydia A. Bazzano, Alison J. Venn, Jorma S. A. Viikari, Nina Hutri-Kähönen, Stephen R. Daniels, Olli T. Raitakari, Costan G. Magnussen, Markus Juonala, Terence Dwyer
Institutions: University of Turku, Turku University Hospital, Murdoch Children's Research Institute, University of Minnesota, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Wake Forest University Health Sciences, Wake Forest University, Royal Children's Hospital, The University of Melbourne, University of Iowa, Tulane University, University of Tasmania, Menzies Institute for Medical Research, Tampere University, Tampere University Hospital, University of Oxford
Language: English
Topic: Cancer Risks and Factors
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,390
OpenAlex ID: W3207998962