Understanding Circadian Mechanisms of Sudden Cardiac Death: A Report From the National Heart, Lung, and Blood Institute Workshop, Part 2: Population and Clinical Considerations
Year: 2021
Type: review
Abstract: Sudden cardiac death (SCD) is the sudden, unexpected death due to abrupt loss of heart function secondary to cardiovascular disease. In certain populations living with cardiovascular disease, SCD follows a distinct 24-hour pattern in occurrence, suggesting day/night rhythms in behavior, the environment, and endogenous circadian rhythms result in daily spans of increased vulnerability. The National Heart, Lung, and Blood Institute convened a workshop, Understanding Circadian Mechanisms of Sudden Cardiac Death to identify fundamental questions regarding the role of the circadian rhythms in SCD. Part 2 summarizes research gaps and opportunities in the areas of population and clinical research identified in the workshop. Established research supports a complex interaction between circadian rhythms and physiological responses that increase the risk for SCD. Moreover, these physiological responses themselves are influenced by several biological variables, including the type of cardiovascular disease, sex, age, and genetics, as well as environmental factors. The emergence of new noninvasive biotechnological tools that continuously measure key cardiovascular variables, as well as the identification of biomarkers to assess circadian rhythms, hold promise for generating large-scale human data sets that will delineate which subsets of individuals are most vulnerable to SCD. Additionally, these data will improve our understanding of how people who suffer from circadian disruptions develop cardiovascular diseases that increase the risk for SCD. Emerging strategies to identify new biomarkers that can quantify circadian health (eg, environmental, behavioral, and internal misalignment) may lead to new interventions and therapeutic targets to prevent the progression of cardiovascular diseases that cause SCD.
Authors: Brian P. Delisle, Alfred L. George, Jeanne M. Nerbonne, Joseph T. Bass, Crystal M. Ripplinger, Mukesh K. Jain, Tracey O. Hermanstyne, Martin E. Young, Prince J. Kannankeril, Jeanne F. Duffy, Joshua I. Goldhaber, Martica H. Hall, Virend K. Somers, Michael H. Smolensky, Christine E. Garnett, Ron C. Anafi, Frank A.J.L. Scheer, Kalyanam Shivkumar, Steven A. Shea, Ravi C. Balijepalli
Institutions: Northwestern University, University of Kentucky, University of California, Los Angeles, Oregon Health & Science University, National Heart, Lung, and Blood Institute, Washington University in St. Louis, University of California, Davis, Case Western Reserve University, University of Alabama, University of Alabama at Birmingham, Vanderbilt University Medical Center, Harvard University, Cedars-Sinai Medical Center, Cedars-Sinai Smidt Heart Institute, University of Pittsburgh, Mayo Clinic, The University of Texas at Austin, United States Food and Drug Administration, University of Pennsylvania
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: Meal Time Effects on Metabolic Health., G207215988, Role of Meal Timing in Efficacy of Bariatric Surgery in Obese Individuals, G2515486903, Impact of Malatonin, Food Timing and Receptor Variant on Type 2 Diabetes Risk, Development of countermeasures against adverse metabolic effects of shift work, G4675729738, Melatonin and Receptor Gene Variant: Linking Circadian System and Type 2 Diabetes, G5400642338, Transcriptional Regulation of KCNH2, G7322499571, Circadian clock regulation of myocardial ion channel expression and function, G8263268693, University of Florida Older Americans Independence Center (OAIC), Endogenous circadian mechanisms underlying cardiovascular risk, Decrypting Variants of Uncertain Significance in Long-QT Syndrome, Sympathetic remodeling and ventricular arrhythmia
OpenAlex ID: W3208055190