Year: 2020
Type: dissertation
Abstract: The adaptive immune system is essential for production of anti-tumor immune responses, with the majority of current immunotherapeutics designed to modulate the interaction between adaptive immunity and tumor cells within the tumor-immune microenvironment. This dissertation addresses three translational goals regarding our understanding and modulation of anti-tumor adaptive immunity: 1) Improvement of understanding for existing immunotherapies such as checkpoint inhibitor therapy (Chapter 2.1); 2) Improvement of efficacy for novel immunotherapeutics currently in development including tumor neoantigen vaccines (Chapter 4); and 3) Development of next-generation immunotherapies through identification of novel anti-tumor vaccine targets (Chapter 3), as well as development of diagnostic tools including biomarkers of immunotherapy response (Chapter 3) and immune-imaging modalities (Chapter 2.1).
DOI: 10.17615/0thg-0m30
Author: Smith, Christof
Institution: University of North Carolina at Chapel Hill
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3208713844