Year: 2021
Type: review
Abstract: Vibrio cholerae O1, the major causative agent of cholera, remains a significant public health threat. Although there are available vaccines for cholera, the protection provided by killed whole-cell cholera vaccines in young children is poor. An obstacle to the development of improved cholera vaccines is the need for a better understanding of the primary mechanisms of cholera immunity and identification of improved correlates of protection. Considerable progress has been made over the last decade in understanding the adaptive and innate immune responses to cholera disease as well as V. cholerae infection. This review will assess what is currently known about the systemic, mucosal, memory, and innate immune responses to clinical cholera, as well as recent advances in our understanding of the mechanisms and correlates of protection against V. cholerae O1 infection.
Language: English
Subfield: Endocrinology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,728
Awards: G1510978416, G2279285589, The gut microbiome and susceptibility to Vibrio cholerae, Antibody mediated protective immunity against cholera, G516757433, G6010259269, Estimating Cholera Burden with Cross-sectional Immunologic Data, Mucosal associated invariant T (MAIT) cells in Vibrio cholerae infection and vaccination, Humoral and adaptive immune responses study in Vibrio cholerae infection, G8951220445, Cross-disciplinary Training in Immunology, Inflammation and Infectious Disease, O-Specific Polysaccharide Responses and Cholera, International research training program in vaccine development and public health, G999781830
OpenAlex ID: W3208743108