Efficacy of Catheter Ablation for Atrial Arrhythmias in Patients with Arrhythmogenic Right Ventricular Cardiomyopathy—A Multicenter Study
Year: 2021
Type: article
Study design: Observational Study
Abstract: Background: Atrial arrhythmias are present in up to 20% of patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). Catheter ablation (CA) is an effective treatment for atrial arrhythmias in the general population. Data regarding CA for atrial arrhythmias in ARVC are scarce. Objective: To assess the safety and efficacy of CA for atrial arrhythmias in patients with ARVC. Methods: In this international collaborative effort, all patients with a definite diagnosis of ARVC undergoing CA for atrial fibrillation (AF), focal atrial tachycardia (AT), or cavotricuspid isthmus (CTI)-dependent atrial flutter (AFl) were extracted from twelve ARVC registries. Demographic, periprocedural, and long-term arrhythmic outcome data were collected. Results: Thirty-seven patients were enrolled in the study (age 50.2 ± 16.6 years, male 84%, CHA2DS2VASc 1 (1,2), HAS-BLED 0 (0–2)). The arrhythmia leading to CA was AF in 23 (62%), focal left AT in 5 (14%), and CTI-dependent AFl in 9 (24%). Acute procedural success was achieved in all procedures but one (n = 1 focal left AT; 97% acute success). The median follow-up period was 27 (13–67) months, and 96%, 74%, and 61% of patients undergoing AF ablation were free from any atrial arrhythmia recurrence after a single procedure at 6 months, 12 months, and last follow-up, respectively. After focal AT ablation, freedom from atrial arrhythmia recurrence was 80%, 80%, and 60% at 6 months, 12 months, and last follow-up, respectively. All patients undergoing CTI ablation were free from atrial arrhythmia recurrences at 6 months, with 89% single-procedural arrhythmic freedom at last follow-up. One major complication (2.7%; PV stenosis requiring PV stenting) occurred. Conclusions: CA is safe and effective in managing atrial arrhythmias in patients with ARVC, with success rates comparable to the general population.
Source: Journal of Clinical Medicine
DOI: 10.3390/jcm10214962
Authors: Alessio Gasperetti, Cynthia A. James, Liang Chen, Niklas Schenker, Michela Casella, Shinwan Kany, Shibu Mathew, Paolo Compagnucci, Andreas Müssigbrodt, Henrik K. Jensen, Anneli Svensson, Sarah Costa, Giovanni B. Forleo, Pyotr G. Platonov, Claudio Tondo, Jiang-Ping Song, Antonio Dello Russo, Frank Ruschitzka, Corinna Brunckhorst, Hugh Calkins, Firat Duru, Ardan M. Saguner
Institutions: Marche Polytechnic University, Johns Hopkins University, University of Zurich, University Hospital Zurich, Azienda Ospedaliero-Universitaria delle Marche, Johns Hopkins Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Fu Wai Hospital, State Key Laboratory of Cardiovascular Disease, Asklepios Klinik St. Georg, Universität Hamburg, University Medical Center Hamburg-Eppendorf, Leipzig Heart Institute, Centre Hospitalier Universitaire de Martinique, Leipzig University, Aarhus University, Aarhus University Hospital, Linköping University, ASST Fatebenefratelli Sacco, Lund University, Skåne University Hospital, University of Milan, Centro Cardiologico Monzino
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,376
OpenAlex ID: W3208771442