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Endocrine Disrupting Chemicals, Transgenerational Epigenetics and Metabolic Diseases.

Year: 2017

Type: article

Abstract: period could be a critical window, altering the epigenome profile. Recently, several researchers suggest a role of EDCs in the obesity epidemic. In this brief review, we focused on how four EDCs (bisphenol A, dichlorodiphenyltrichloroethane, di-(2-ethylhexyl) phthalate and tributyltin) may underlay transgenerational epigenetic effects. We also discuss the adipogenesis signaling pathway and the impact of exposure to individual or mixtures of EDCs on the developing endocrine system. Understanding the molecular determinants of epigenetic memory across generations will provide essential insight into how environmental exposure can affect the health of individuals, as well as subsequent generations.

Source: PubMed

Authors: Aliya Feroe, Richard Broene, David Albuquerque, Patricia Ruiz

Institutions: Harvard University, Bowdoin College, University of Coimbra, Agency for Toxic Substances and Disease Registry

Language: English

Topic: Effects and risks of endocrine disrupting chemicals

Subfield: Health, Toxicology and Mutagenesis

Field: Environmental Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3208877262

FWCI:

Cites: 130

Cited by: 7

Related to: 10