Cross-species screening platforms identify EPS-8 as a critical link for mitochondrial stress and actin stabilization
Year: 2021
Type: article
Abstract: regulation through integrin-mediated remodeling of the actin cytoskeleton. This study also highlights the use of cross-species comparisons in genetic screens to interrogate cellular pathways.
Source: Science Advances
Authors: Erica A. Moehle, Ryo Higuchi-Sanabria, C. Kimberly Tsui, Stefan Homentcovschi, Kevin M. Tharp, Hanlin Zhang, Hannah Chi, Larry Joe, Mattias de los Rios Rogers, Arushi Sahay, Naame Kelet, Camila Benitez, Raz Bar-Ziv, Gilberto Garcia, Koning Shen, Phillip A. Frankino, Robert T. Schinzel, Ophir Shalem, Andrew Dillin
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,500
Funders: Howard Hughes Medical Institute, Larry L. Hillblom Foundation, Glenn Foundation for Medical Research, University of California Berkeley, National Institutes of Health, National Institute on Aging, National Cancer Institute, National Institute of Neurological Disorders and Stroke, National Institute of Environmental Health Sciences
Awards: Pacific Biosciences PacBio RS Single Molecule Real Time Sequencer, G1704284401, Mechanical stress reprograms mitochondrial metabolism to support tumor survival and invasion through the mitochondrial unfolded protein response, Dissecting the mechanisms that underlie mislocalization and aggregation of RNA binding proteins in neurodegenerative diseases, G3435140923, The Perception of Mitochondrial Stress in Receiving Cells, G3875678782, G3902268349, More than just a load control: cytoskeletal form and function during aging, The Collapse of Proteostasis during Aging is Mediated by Cytoskeletal Actin Functions, Neuroendocrine Coordination of Mitochondrial Stress Signaling and Proteostasis, G9000028377, Caenorhabditis Genetics Center
OpenAlex ID: W3209031240