Work

Astrocytes contribute to pain gating in the spinal cord

Year: 2021

Type: article

Abstract: neurons and pain inhibition by Aβ-fiber stimulation. Collectively, our study introduces astrocytes as an important component of pain gating by activation of Aβ-fibers, which thus exert nonneuronal control of pain.

Source: Science Advances

DOI: 10.1126/sciadv.abi6287

Authors: Qian Xu, Neil C. Ford, Shaoqiu He, Qian Huang, Michael Anderson, Zhiyong Chen, Fei Yang, LaTasha K. Crawford, Michael J. Caterina, Yun Guan, Xinzhong Dong

Institutions: Howard Hughes Medical Institute, Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: Pain Mechanisms and Treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,500

Funders: National Institute of Neurological Disorders and Stroke, National Institute of Dental and Craniofacial Research

Awards: G1434836478, G2329918419, G2550138661, G4123324293, Functional Analysis of Mrgpr Family in itch sensation, G8184620170

OpenAlex ID: W3209216158

FWCI: 7.024

Cites: 65

Cited by: 84

Related to: 10