Work

Taming the Wild-Type Gastrointestinal Stromal Tumor: Improved Tissue Culture

Year: 2021

Type: article

Abstract: Wild-type gastrointestinal stromal tumors (WT GIST) are most frequently characterized by succinate dehydrogenase (SDH) deficiency. Reliable ex vivo tumor models have been difficult to develop given the downstream metabolic effects of SDH deficiency. Improved tumor modeling approaches are needed to develop effective systemic treatment options for patients with WT GIST. See related article by Yebra et al., p. 187

Source: Clinical Cancer Research

DOI: 10.1158/1078-0432.ccr-21-3409

Authors: Andrew M. Blakely, John W. Glod, Mary Frances Wedekind Malone

Institutions: National Institutes of Health, National Cancer Institute

Language: English

Topic: Gastrointestinal Tumor Research and Treatment

Subfield: Gastroenterology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institutes of Health