MC3R links nutritional state to childhood growth and the timing of puberty

Year: 2021

Type: article

Authors: B. Y. H. Lam, A. Williamson, S. Finer, F. R. Day, J. A. Tadross, A. Gonçalves Soares, K. Wade, P. Sweeney, M. N. Bedenbaugh, D. T. Porter, A. Melvin, K. L. J. Ellacott, R. N. Lippert, S. Buller, J. Rosmaninho-Salgado, G. K. C. Dowsett, K. E. Ridley, Z. Xu, I. Cimino, D. Rimmington, K. Rainbow, K. Duckett, S. Holmqvist, A. Khan, X. Dai, E. G. Bochukova, R. C. Trembath, H. C. Martin, A. P. Coll, D. H. Rowitch, N. J. Wareham, D. A. van Heel, N. Timpson, R. B. Simerly, K. K. Ong, R. D. Cone, C. Langenberg, J. R. B. Perry, G. S. Yeo, S. O’Rahilly

Institutions: University of Cambridge, Wellcome/MRC Institute of Metabolic Science, MRC Metabolic Diseases Unit, NIHR Cambridge Biomedical Research Centre, MRC Epidemiology Unit, Queen Mary University of London, University of Bristol, MRC Integrative Epidemiology Unit, University of Michigan, Vanderbilt University, University of Exeter, German Institute of Human Nutrition, Unidade Local de Saúde de Coimbra, Blizard Institute, King's College London, Wellcome Sanger Institute, Berlin Institute of Health at Charité - Universitätsmedizin Berlin

Language: English

Topic: Hypothalamic control of reproductive hormones

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: AstraZeneca, Wellcome Trust, Broad Institute, Barts Charity, Cancer Research UK, National Institute for Health and Care Research, Diabetes Research and Wellness Foundation, Department of Health and Social Care, University of Cambridge, King's College London, University of Bristol, Public Health England, Cambridge University Hospitals, Barts Health NHS Trust, National Institutes of Health, Horizon 2020 Framework Programme, Elizabeth Blackwell Institute for Health Research, University of Bristol, Medical Research Council, Biotechnology and Biological Sciences Research Council, NIHR Cambridge Biomedical Research Centre, Cancer Research UK Cambridge Institute, University of Cambridge, National Institute of Diabetes and Digestive and Kidney Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: G1075599542, Aetiology of type 2 diabetes and related metabolic disorders, High Throughput Science - Investigating pathways to metabolic disease using "omic" approaches, G1131969086, G139696651, G1465635051, Institutional Strategic Support Fund, G1684393010, Modelling neurodevelopmental and molecular mechanisms of human genetic obesity, G173885373, Mechanisms in Disorders of Energy Balance, G1793884970, High Throughput Science - Investigating the genetic determinants of healthy ageing: the MRC EPIC-Norfolk study, G2083818045, G2232211415, Characterization of human neurons expressing the glucagon-like peptide 1-receptor (GLP1-R), G2438974996, G2479680678, East London Genes & Health: human knockouts in a population genomic medicine cohort of British-South Asians, G2642749895, G2892497062, G299057155, G303234583, G3060977130, G3104359497, G316823364, Insights into metabolic health and disease from human genetic variants with major functional impact, G3288322216, G3344456887, G339059223, G3417935152, G3507283293, G3652455175, The Avon Longitudinal Study of Parents and Children (ALSPAC): A multi- generation, longitudinal resource focusing on life course health and well- being., G3698063609, G370598735, G3812975344, G385201875, G3889866591, G3909006727, G3971076793, G3987754321, G4025249204, G4075560779, G4141580393, G4182978079, G4264126553, Enabling technologies, G4409035895, What lies behind the causal impact of body mass index (BMI) level and change on human health? Added value from complementary study design and deep metabolomic phenotyping., G469522804, G485284085, The EPIC-Norfolk prospective population study: biological and behavioural determinants of health and disease in an ageing population, G5036201495, G515689015, G527520901, G5304221363, G5313676757, G5315906942, G5517677352, The University of Cambridge Metabolic Research Laboratories, Wellcome-MRC Institute of Metabolic Science, Cambridge, Institutional Strategic Support Fund, G5575271627, G5721934943, G5787426001, G5897142711, Mapping the human hypothalamic functional architecture underlying food intake control, G6003569275, G6049260834, G6058803565, G6098506882, NIHR Senior Investigator Award, G6206044308, G6208931321, G6223152210, G624298721, G6432094593, G6594529311, G6641991021, G6682065591, G6689231961, G6846557028, G6870695443, G6957823285, G7211668644, G7320971488, G7826725679, The Avon Longitudinal Study of Parents and Children (ALSPAC): A multi-generation, longitudinal resource focusing on life course health and well-being., Role of the Melanocortin-3 Receptor in Regulation of the HPG Axis, G8198795195, G8205009473, What lies behind the causal impact of body mass index (BMI) level and change on human health? Added value from complementary study design and deep metabolomic phenotyping., G8502142660, Child Growth and development, G8858395165, G8975348055, G8989877850, G899966268, G9000006066, G953086832

OpenAlex ID: W3209414730