Work

Automated glycan assembly of peptidoglycan backbone fragments

Year: 2021

Type: article

Abstract: We report the automated glycan assembly (AGA) of different oligosaccharide fragments of the bacterial peptidoglycan (PGN) backbone. Iterative addition on a solid support of an acetyl glucosamine and a new muramic acid building block is followed by cleavage from the solid support and final deprotection providing 10 oligosaccharides up to six units.

Source: Organic & Biomolecular Chemistry

DOI: 10.1039/d1ob01987b

Authors: Pietro Dallabernardina, Valentina Benazzi, Jon D. Laman, Peter H. Seeberger, Felix F. Loeffler

Institutions: Max Planck Institute of Colloids and Interfaces, University of Pavia, University Medical Center Groningen, Freie Universität Berlin

Language: English

Topic: Carbohydrate Chemistry and Synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Funders: Bundesministerium für Bildung und Forschung, Max-Planck-Gesellschaft

Awards: G3550781690, Erforschung einer neuen Methode für die Herstellung von hochdichten Molekülbibliotheken (cLIFT)