Work

Structural analysis of fibrillar polymorphs in AD (Alzheimer disease) brain tissue and pair distribution function of associated fibrils

Year: 2021

Type: article

Abstract: X-ray microdiffraction in the SAXS (Small Angle X-ray scattering) and WAXS (Wide Angle X-ray scattering) regimes can be used to probe the structural organization of amyloid and NFT (Neurofibrillary tangle) deposits in thin section of tissue from AD subjects. The Wide-angle X-ray scattering from these deposits is dominated by a layer line at 4.7 AX-ray microdiffraction in the SAXS (Small Angle X-ray scattering) and WAXS (Wide Angle Xray scattering) regimes can be used to probe the structural organization of amyloid and NFT (Neurofibrillary tangle) deposits in thin section of tissue from AD subjects. The Wide-angle X-ray scattering from these deposits is dominated by a layer line at 4.7 spacing which provides insight into fibrillar structure. The polymorphism of these structures is being analyzed using data from the SAXS regime that generates information about cross-sectional shape/ size and cylindrical pair distribution function of fibrils involved.

Source: Acta Crystallographica Section A Foundations and Advances

DOI: 10.1107/s0108767321098913

Authors: Prakash Nepal, Abdullah Al Bashit, Lee Makowski

Institution: Northeastern University

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

Open Access status: bronze

Funder: National Institutes of Health

OpenAlex ID: W3209766686