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Initiatives to Build a Whole-Cell Modeling Community: 2019 Update

Year: 2019

Type: report

Abstract: Whole-cell (WC) models that predict phenotype from genotype have the potential to transform biology, bioengineering, and medicine. Achieving WC models will likely require collaboration among modelers, experimentalists, mathematicians, computer scientists, and engineers. In 2012, we and others began to build a WC community by organizing a central website, a primer, schools, hackathons, and challenges. This year, we have continued to build a WC community by developing a new website, expanding the primer, organizing a third school, and launching an online seminar. Here, we summarize these initiatives, their impact to date, and our plans to continue to build a WC community.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.3063172

Authors: Karr, Jonathan R, Lluch-Senar, Maria, Kastelic, Damjana, Serrano, Luis, Sauro, Herbert M

Institutions: Icahn School of Medicine at Mount Sinai, Centre for Genomic Regulation, University of Washington

Language: English

Topic: Gene Regulatory Network Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Science Foundation

Awards: INSPIRE: Systematic, scalable representation and simulation of whole-cell models, ERASynBio: MiniCell - A Model-driven Approach to Minimal Cell Engineering

OpenAlex ID: W3209895567

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