Viral Coinfection is Associated with Improved Outcomes in Emergency Department Patients with SARS-CoV-2
Year: 2021
Type: article
Study design: Observational Study
Abstract: INTRODUCTION: Coinfection with severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) and another virus may influence the clinical trajectory of emergency department (ED) patients. However, little empirical data exists on the clinical outcomes of coinfection with SARS-CoV-2 METHODS: In this retrospective cohort analysis, we included adults presenting to the ED with confirmed, symptomatic coronavirus 2019 who also underwent testing for additional viral pathogens within 24 hours. To investigate the association between coinfection status with each of the outcomes, we performed logistic regression. RESULTS: Of 6,913 ED patients, 5.7% had coinfection. Coinfected individuals were less likely to experience index visit or 30-day hospitalization (odds ratio [OR] 0.57; 95% confidence interval [CI], 0.36-0.90 and OR 0.39; 95% CI, 0.25-0.62, respectively). CONCLUSION: Coinfection is relatively uncommon in symptomatic ED patients with SARS-CoV-2 and the clinical short- and long-term outcomes are more favorable in coinfected individuals.
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $500
Funders: Massachusetts General Hospital, University of Pennsylvania, Northwestern University, George Washington University, University of Chicago, Washington University in St. Louis, University of Texas Southwestern Medical Center, Thomas Jefferson University, University of South Carolina, University of Texas Health Science Center at Houston, University of Illinois at Urbana-Champaign, School of Medicine, Indiana University
OpenAlex ID: W3209928003