Non-mental diseases associated with ADHD across the lifespan: Fidgety Philipp and Pippi Longstocking at risk of multimorbidity?
Year: 2021
Type: review
Abstract: Several non-mental diseases seem to be associated with an increased risk of ADHD and ADHD seems to be associated with increased risk for non-mental diseases. The underlying trajectories leading to such brain-body co-occurrences are often unclear - are there direct causal relationships from one disorder to the other, or does the sharing of genetic and/or environmental risk factors lead to their occurring together more frequently or both? Our goal with this narrative review was to provide a conceptual synthesis of the associations between ADHD and non-mental disease across the lifespan. We discuss potential shared pathologic mechanisms, genetic background and treatments in co-occurring diseases. For those co-occurrences for which published studies with sufficient sample sizes exist, meta-analyses have been published by others and we discuss those in detail. We conclude that non-mental diseases are common in ADHD and vice versa and add to the disease burden of the patient across the lifespan. Insufficient attention to such co-occurring conditions may result in missed diagnoses and suboptimal treatment in the affected individuals.
Authors: Sarah Kittel-Schneider, Gara Arteaga-Henriquez, Alejandro Arias Vasquez, Phil Asherson, Tobias Banaschewski, Isabell Brikell, Jan Buitelaar, Bru Cormand, Stephen V. Faraone, Christine M. Freitag, Ylva Ginsberg, Jan Haavik, Catharina A. Hartman, Jonna Kuntsi, Henrik Larsson, Silke Matura, Rhiannon V. McNeill, J. Antoni Ramos-Quiroga, Marta Ribases, Marcel Romanos, Isabella Vainieri, Barbara Franke, Andreas Reif
Institutions: Goethe University Frankfurt, Universitätsklinikum Würzburg, University Hospital Frankfurt, Universitat Autònoma de Barcelona, Centro de Investigación Biomédica en Red de Salud Mental, Vall d'Hebron Institut de Recerca, Vall d'Hebron Hospital Universitari, Radboud University Nijmegen, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, King's College London, Heidelberg University, Central Institute of Mental Health, Medizinische Fakultät Mannheim, Aarhus University, Karolinska Institutet, Lundbeck Foundation, Centre for Biomedical Network Research on Rare Diseases, Institut de Recerca Sant Joan de Déu, Institut de Biomedicina de la Universitat de Barcelona, Universitat de Barcelona, SUNY Upstate Medical University, Region Stockholm, Stockholm Health Care Services, Haukeland University Hospital, University of Bergen, University Medical Center Groningen, University of Groningen, Örebro University, University of Würzburg
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: Stiftelsen Kristian Gerhard Jebsen, Deutscher Akademischer Austauschdienst, Bundesministerium für Bildung und Forschung, Generalitat de Catalunya, Ministerio de Economía y Competitividad, Lundbeckfonden, European College of Neuropsychopharmacology, H. Lundbeck A/S, Horizon 2020 Framework Programme, Agència de Gestió d'Ajuts Universitaris i de Recerca, Instituto de Salud Carlos III, European Regional Development Fund
Awards: G1324743122, G214445032, G2628364946, G2654049849, G2713162615, G2783655308, Impacto del Riesgo Genético Acumulado para el Trastorno por Déficit de Atención con Hiperactividad en las Drogodependencias e Identificación de la Base Genética Compartida, G3246699782, G3552952322, G363525713, G3987400284, G4077098235, G4167878811, G5713677518, G5808246334, G6298273575, G6332337720, G697019932, G7082884047, G7320609940, G837377678, G8824911526
OpenAlex ID: W3209970818