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A primer on harnessing non-enzymatic post-translational modifications for drug design

Year: 2021

Type: article

Abstract: Our primer discusses the current issues faced when medicinal chemists try to leverage highly reactive electrophiles for drug development.

Source: RSC Medicinal Chemistry

DOI: 10.1039/d1md00157d

Authors: Marcus J. C. Long, Phillippe Ly, Yimon Aye

Institutions: University of Lausanne, École Polytechnique Fédérale de Lausanne

Language: English

Topic: Click Chemistry and Applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: École Polytechnique Fédérale de Lausanne, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Award: Deconstructing precision signaling crosstalk regulated by native reactive electrophiles

OpenAlex ID: W3210266621

FWCI: 0.198

Cites: 65

Cited by: 2

Related to: 10