Work

IL-17 and IL-17C Signaling Protects the Intestinal Epithelium against Diisopropyl Fluorophosphate Exposure in an Acute Model of Gulf War Veterans' Illnesses

Year: 2021

Type: article

Abstract: , acute DFP exposure negatively impacts the mucosal epithelium by reducing tight junction proteins and antimicrobial peptides as well as altering intestinal microbiome composition. Furthermore, DFP treatment reduced the expression of IL-17 in the colonic epithelium. Conversely, both IL-17 and IL-17C treatment could combat the negative effects of DFP and other cholinesterase inhibitors in murine intestinal organoid cells. Our findings demonstrate that acute exposure to DFP can result in rapid deterioration of mechanisms protecting the GI tract from disease. These results are relevant to suspected GWI exposures and could help explain the propensity for GI disorders in GWI Veterans.

Source: Immune Network

DOI: 10.4110/in.2021.21.e35

Authors: Kristen M. Patterson, Tyler G. Vajdic, Gustavo J. Martinez, Axel G. Feller, Joseph M. Reynolds

Institutions: Rosalind Franklin University of Medicine and Science, Captain James A. Lovell Federal Health Care Center

Language: English

Topic: Pesticide Exposure and Toxicity

Subfield: Plant Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: U.S. Department of Veterans Affairs, National Institutes of Health, National Center for Advancing Translational Sciences