Work

Structure–Property Relationship Study of N -(Hydroxy)Peptides for the Design of Self-Assembled Parallel β-Sheets

Year: 2020

Type: article

Abstract: The design of novel and functional biomimetic foldamers remains a major challenge in creating mimics of native protein structures. Herein, we report the stabilization of a short b-sheet by incorporating N-(hydroxy)glycine (Hyg) residues into the backbone of peptides. These short peptide−peptoid hybrids form unique parallel b-sheet structures by self-assembly. Spectroscopic and crystallographic data collected suggest that the local conformational perturbations induced by N-(hydroxy)amides are outweighed by a network of strong interstrand hydrogen-bonds.

Source: The Journal of Organic Chemistry

DOI: 10.1021/acs.joc.0c01441

Authors: Alexis D. Richaud, Stéphane P. Roche

Institution: Florida Atlantic University

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: University of Florida, National Institutes of Health, National Institute of General Medical Sciences

Awards: Acquisition of a Q Exactive HF Hybrid Quadrupole-Orbitrap, Flexible Rigidity in Peptide Drug Design for Protein-Protein Interaction Inhibitors, G5572547113, G746412539