A Novel Bioengineered Material to Reverse Intervertebral Disc Degeneration
Year: 2020
Type: article
Abstract: Intervertebral disc degeneration (IDD) is a major cause of chronic and debilitating back pain whose prevalence and severity make it a major health issue of substantial socioeconomic importance. The prevalence of chronic disabling back pain has tripled over the last 20 years [1] and the treatment of lower back pain in the United States is estimated to cost more than $100 billion per year. [2] Current treatment options are mostly palliative since disc tissue has little intrinsic repair capacity once a matrix synthesis/degradation imbalance occurs. Our bioengineered naturally secreted compositions have demonstrated the ability to decrease/remove protease and inflammatory cytokine activity and stimulate native cells to secrete new matrix production in vitro, and to maintain nucleus hydration and help to recover from the initial disc height loss in the semi-acute rabbit annular puncture model.
Authors: Fukui, Daisuke, Masuda, Koichi, Zimber, Michael, Adachi, Stephanie Y., Arimoto, Natsuko, Kim, Jeong Ho, Latterich, Martin, Naughton*, Gail K.
Institutions: University of California San Diego, Histogen (United States)
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6912579122